Cell autonomous requirement for TGF-β signaling during odontoblast differentiation and dentin matrix formation
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چکیده
منابع مشابه
Cell autonomous requirement for TGF-β signaling during odontoblast differentiation and dentin matrix formation
TGF-beta subtypes are expressed in tissues derived from cranial neural crest cells during early mouse craniofacial development. TGF-beta signaling is critical for mediating epithelial-mesenchymal interactions, including those vital for tooth morphogenesis. However, it remains unclear how TGF-beta signaling contributes to the terminal differentiation of odontoblast and dentin formation during to...
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Dentin is the major part of tooth and formed by odontoblasts. Under the influence of the inner enamel epithelium, odontoblasts differentiate from ectomesenchymal cells of the dental papilla and secrete pre-dentin which then undergo mineralization into dentin. Transforming growth factor-beta (TGF-β)/bone morphogenetic protein (BMP) signaling is essential for dentinogenesis; however, the precise ...
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ژورنال
عنوان ژورنال: Mechanisms of Development
سال: 2007
ISSN: 0925-4773
DOI: 10.1016/j.mod.2007.02.003